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Choloylglycine hydrolase
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Choloylglycine hydrolase : ウィキペディア英語版
Choloylglycine hydrolase

In enzymology, a choloylglycine hydrolase () is an enzyme that catalyzes the chemical reaction
:3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine + H2O \rightleftharpoons 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + glycine
Thus, the two substrates of this enzyme are 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine and H2O, whereas its two products are 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate and glycine.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase. Other names in common use include glycocholase, bile salt hydrolase, and choloyltaurine hydrolase. This enzyme participates in bile acid biosynthesis.
==Structural studies==

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes , , , and .

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